Endocrine Abstracts

Regulation of the epithelial sodium channel (ENaC) trafficking in cells of the distal nephron is of major importance in the control of sodium reabsorption. Mutations in the genes compromising the molecular pathway by which corticosteroids regulate ENaC sodium reabsorption cause several hypertensive syndromes in humans. The molecular events underpinning ENaC exo- and endocytosis and the hormonal effects on ENaC trafficking are poorly understood. To start elucidating these pathw...

The foetus of a mother with previous or current Graves disease is at risk of developing thyrotoxicosis. The mother can act as a bioassay to diagnose foetal thyrotoxicosis. We describe the difficulties in managing foetal thyrotoxicosis in a mother who could not act as a bioassay because of previous Graves disease treated by total thyroidectomy.A 35year old woman fell pregnant 3 months after a total thyroidectomy for relapsed Graves disease and concomitant...

Serum gastrin (G) levels >1000 pg usually raise the suspicion for a neuroendocrine tumor (NET) secreting G. Rarely, such elevated G levels are seen in pts with pernicious anemia (PA) which most commonly is associated with autoimmune gastritis (AG) (1). AG can occur concomitantly with other autoimmune d/o incl. lymphocytic colitis (LC) (2). G stimulates enterochromaffin-like cells which increase histamine (H) secretion. H excess can cause diarrhea (D) as can bacterial overg...